Metabolomics is defined as a large-scale study of small molecules in the body known as metabolites (the intermediate and final products of metabolism), as well as their biological interaction.
Initiating research in this area, the Estée Lauder Companies has opened up new ideas for skin care. They were presented at the world Congress of dermatology (WCD) in 2019 in Milan, Italy.
The research group included scientists Leihong Xiang and Nadine Pernode from Estée Lauder Companies; Paolo Sasson-Corsi, University of California; kirk Beebe, Metabolon, Inc. They argue that metabolomics illustrates the complex relationship between genetics and the environment, revealing how both play a role in the skin and how their changes reflect the condition of the skin.
First of all, the scientists were able to characterize the circadian metabolism (the rhythm of metabolism that is based on the alternation of day and night) skin of young and elderly people. The study was able to temporarily determine the metabolome of the skin by assessing the dynamics of circadian rhythms in the Horny layer of the human using non-invasive methods of data collection. The results clearly showed that the natural rhythm of the metabolism of young skin. “This study gives a deeper understanding of skin aging and specifies the temporary metabolome of human skin, showing, thus, dependent on the circadian rhythm of changes in the processes of restoration and protection of the skin of the person. And finally, this is the first study that shows that treatment can help natural regeneration of the skin,” say the researchers.
Autophagy is associated with inflammatory processes in the skin cells. According to the research team, Estée Lauder Companies, autophagy (the process of recycling a cell’s own components) is a main pathway of cellular degradation and recycling, is crucial to cell longevity and is associated with the aging process. The reduction processes of autophagy leads to increased cell damage with age. For the first time in the skin cells, a connection between autophagy and phase of inflammation, which gives evidence of their involvement in the protection of the skin from prolonged inflammation and its visible effects.
In the light of new data, the researchers also determined the efficacy of the enzyme species of brown algae – macrocystis pyrifera (Macrocystis pyrifera.) Studies have shown that inflammation, especially chronic, is a potential cause of accelerated aging of the skin. Elimination of inflammation is a coordinated and dynamic process, which reduces inflammation and provides a natural skin regeneration and helps the skin to preserve its natural integrity.
Thus, anti-inflammatory properties of the enzyme Macrocystis pyrifera from the family of laminaria may facilitate rapid recovery of the skin. The results show that the use of the enzyme of the algae effective against all phases of inflammation and enhancing migration of fibroblasts, which allows the skin to preserve its natural integrity.
A multi-stage approach to the treatment of acne has significantly reduced damage to the skin pravymi lesions after 12 weeks of treatment. The pathogenesis of acne is complex, with compelling evidence supporting the involvement of sebaceous gland hyperplasia, follicular hyperkeratinization, bacterial hyperboloidal and inflammation. For acne and related disorders of the biological functions of the body, the researchers used multi-purpose compound to evaluate its effect on the total number of lesions in populations with acne. The results showed that the treatment significantly reduced the total number of lesions after 12 weeks.