According to researchers from the University of California San Francisco (UCSF) Medical center and veterans Affairs San Francisco (SFVA), hydrated skin can prevent age-related diseases, including Alzheimer’s disease, heart disease, and diabetes.
Representatives of the industry of cosmetics and personal care products know that the skin is the largest organ of the body, so to care for it use an integrated approach, particularly in eliminating the signs of aging. However, cosmetics manufacturers often forget that the negative condition of the skin can affect the overall health of the person. This problem was highlighted in a new study by dermatologists from UCSF and SFVA.
According to research, with age, people have seen a low level inflammation caused by the increase in the number of molecules in the blood known as cytokines. This age-related inflammation associated with chronic diseases, including Alzheimer’s disease, cardiovascular disease and diabetes. Although scientists suspected that the inflammation caused by the immune system or liver, but a group of dermatologists from San Francisco was another theory.
“The inflammation must come from the body large enough for even very small manifestations can affect the whole body. Leather is best suited for this purpose because of its size,” explains senior author of the study, Mao-Qiang man, MD, researcher at UCSF working in the health care system SFVA, who is also an adjunct Professor of southern medical University in Guangzhou, China.
Mr man added that during aging there are such dermatological symptoms like pruritus, dryness and alteration of the acidity of the skin. Thus, although the skin may occur a slight inflammation because of its size relative to the body, it boosts the level of circulating cytokines. In addition, the skin condition begins to deteriorate at the age of about 50 years, evidence of which are the changes of pH level of the epidermis, moisture loss, or destruction of the permeability barrier, which could also result in the evolution of skin inflammatory cytokines.
While normally cytokines help to repair the defects in the barrier in aging skin is not so easy to do so these substances penetrate into the blood. “Until recently, the scientific community did not believe that the skin can contribute to systemic inflammation and disease, says the study’s lead author Theodora Mauro, MD, Professor of dermatology at UCSF and SFVA. But over the past five years the research of psoriasis and dermatitis have shown that inflammation of the skin in these diseases, probably increases the risk of heart disease”.
In their study, the scientists used skin cream with special composition, which consisted of cholesterol, free fatty acids and ceramides that help restore the skin. Thirty-three people ranging in age from 58 to 95 years applied the cream all over my body twice a day for 30 days. A month later, the researchers measured blood levels of three cytokines: beta-interleukin-1, interleukin-6 and alpha-tumor necrosis factor (TNF), all of which are indicators of inflammatory diseases associated with aging.
The use of the cream helped to reduce the number of all three kinds of cytokines compared with levels of participants before applying the cream, and the levels of adults of the same age who have not used the cream. In fact, the use of the cream, as reported by the researchers, reduced the level of cytokines of the participants to the level characteristic of the age of 30.
In the future, the researchers will study the possibility of using such a cream to maintain the normal function of the epidermis as people age and prevent the development of diseases of other organs.
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17 April, Moscow will host the conference of the company Mesopharm “a Scientific approach to aesthetic medicine. Current issues and trends in the industry.”