The protective system of the skin contribute to the growth of its sensitivity


In connection with climate change, leading to more dry and hot air in summer, environmental pollution, increased stress and allergic reactions, more and more people throughout the world suffer from sensitive skin, which is associated with pain, itching and burning.

Overall, 60 to 70% of women and 50 to 60% of men report some degree of skin sensitivity. Chronic effects on sensitive skin possible visible signs of discomfort, such as redness. This negatively affects the quality of people’s lives, as it affects social and psychological well-being. A recently published study showed that 34.5% of adults with advanced sensitive skin limit your way of life, and 17.7 percent avoided social interactions because of their appearance. Therefore, the prevention of sensitive skin or the repair at the first signs of using effective means for skin care is a priority for cosmetic manufacturers.

Although researchers have yet to understand all the causes of sensitive skin, there is another mechanism that could explain the overall sensitivity of the skin dysfunction of the epidermal barrier associated with this reaction. Weakened barrier function occurs because of changes in the stratum corneum. When the thickness of the layer of corneocyte decreases or when the adhesion between the cells is weakened, for example as a result of the natural aging process or when people scratch itchy skin, irritants easier and to penetrate deeper into the skin.

There they are detected by the system protect the skin and initiate a chain reaction that leads to the secretion of irritating mediators of Th2 lymphocytes secrete interleukins, fibroblasts produce eotaxin to attract eosinophils, which, in turn, encourage fat cells to release histamine. This acute response leads to the removal of these irritants and protects the skin. But when one substance acts on the skin constantly, the security system changes its mechanism of action. Even minor contact cause disproportionate reactions with the release of a large number of molecules of the stimulus.

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The epidermis, damaged by chronic rastarivanie, leads to a vicious cycle of itch – scratch, producing even more histamine, and preventing the calm the skin. Thus, the modulation of the response to irritants is key to preventing violations of the regulation of skin sensitivity and gaining control of related to skin problems.

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